Mass Effect Andromeda
Mass Effect Andromeda is an upcoming entry in the Mass Effect series, taking place in the future and far removed from the first 3 games. It will run on the Frostbite 3 engine, the same as Battlefield 4. It is expected to use the Denuvo DRM mechanism which has been part of recent EA games. This will make it difficult to modify the game for some time once it's launched. The tentative release date is early 2017.
Obviously there are no mods yet.